Desmoglein, the target molecule in autoimmunity and infection

Desmoglein 1 and desmoglein 3 are the target autoantigens in herpetiform pemphigus.

OBJECTIVE To determine the cell surface autoimmune target of herpetiform pemphigus (HP). DESIGN Serum samples of HP were examined by immunoblot studies with human epidermal extracts, enzyme-linked immunosorbent assay with baculovirus-expressed recombinant desmoglein (rDsg) 1 and rDsg3, and immunoadsorption assay with rDsg. PATIENTS Twenty serum samples were obtained from patients with HP wh...

Desmoglein as a target in skin disease and beyond

Much of the original research on desmosomes and their biochemical components was through analysis of skin and mucous membranes. The identification of desmogleins 1 and 3, desmosomal adhesion glycoproteins, as targets in pemphigus, a fatal autoimmune blistering disease of the skin and mucous membranes, provided the first link between desmosomes, desmogleins, and human diseases. The clinical and ...

the relationship between learners critical thinking ability and their performance in the reading sections of the tofel and ielts test

the study reflected in this thesis aims at finding out relationships between critical thinking (ct), and the reading sections of tofel and ielts tests. the study tries to find any relationships between the ct ability of students and their performance on reading tests of tofel and academic ielts. however, no research has ever been conducted to investigate the relationship between ct and the read...

Infection and Autoimmunity

Infection and Autoimmunity

As the editors imply in their introduction, the relationship of infection and autoimmunity is complex, compelling, and best viewed as a physiologic process and potential consequence of normal immune recognition and immunoregulation. The editors boldly state that reading the chapters in this book brings one to the conclusion that all autoimmune diseases are infectious, until proven otherwise (my...